Premarin Coupon - Premarin 0.3mg tablet

Premarin (conjugated estrogens) is used to treat hot flashes and prevent osteoporosis, low hormone levels or in those who have had their ovaries removed. This drug is slightly less popular than other estrogens. There are currently no generic alternatives to Premarin.

GoodRx has partnered with InsideRx and Pfizer to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Premarin is covered by most Medicare and insurance plans.

Premarin Coupon - Premarin 0.3mg tablet

Premarin Side Effects

What should I watch for?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

The tablet shell for some brands of this medicine does not dissolve. The tablet shell may appear whole in the stool. This is not a cause for concern. If you see something that resembles a tablet in your stool, talk to your healthcare provider.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.


Common and Rare Side Effects

Women rarely have severe side effects from taking estrogens to replace estrogen. Discuss these possible effects with your doctor:

The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than 1 year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.

Although the incidence is low, the use of estrogens may increase you chance of getting cancer of the breast. Breast cancer has been reported in men taking estrogens.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

The following side effects may be caused by blood clots, which could lead to stroke, heart attack, or death. These side effects occur rarely, and, when they do occur, they occur in men treated for cancer using high doses of estrogens.

Check with your doctor immediately if any of the following side effects occur:

More common

Breast pain (in females and males)

fast heartbeat




increased breast size (in females and males)

irritation of the skin

itching of the skin

joint pain, stiffness, or swelling


redness of the skin

shortness of breath

swelling of the eyelids, face, lips, hands, or feet

swelling of the feet and lower legs

tightness in the chest

troubled breathing or swallowing

weight gain (rapid)


Less common or rare

Changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding)

chest pain



heavy non-menstrual vaginal bleeding

lumps in, or discharge from, breast (in females and males)

pains in the stomach, side, or abdomen

yellow eyes or skin


for males being treated for breast or prostate cancer only

Headache (sudden or severe)

loss of coordination (sudden)

loss of vision or change of vision (sudden)

pains in the chest, groin, or leg, especially in the calf of leg

shortness of breath (sudden and unexplained)

slurring of speech (sudden)

weakness or numbness in the arm or leg

Incidence not known

Abdominal or stomach bloating

abdominal or stomach cramps

acid or sour stomach





blistering, peeling, or loosening of the skin

blue-yellow color blindness

blurred vision

change in vaginal discharge

changes in skin color

changes in vision

chest discomfort

clay-colored stools

clear or bloody discharge from nipple




dark urine

decrease in the amount of urine

decreased vision



difficulty with breathing

difficulty with speaking

dimpling of the breast skin


double vision

dry mouth

eye pain


fluid-filled skin blisters

full feeling in upper abdomen or stomach

full or bloated feeling or pressure in the stomach



inability to move the arms, legs, or facial muscles

inability to speak

incoherent speech

increased urination


inverted nipple

irregular heartbeats

light-colored stools


loss of appetite

loss of bladder control

lump under the arm

metallic taste

migraine headache

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

muscle pain

muscle spasm or jerking of all extremities

muscle weakness


noisy breathing

numbness or tingling of the hands, feet, or face

pain in the ankles or knees

pain or discomfort in the arms, jaw, back or neck

pain or feeling of pressure in the pelvis

pain, tenderness, swelling of the foot or leg

painful or tender cysts in the breasts

painful, red lumps under the skin, mostly on the legs

pains in the chest, groin, or legs, especially calves of the legs

partial or complete loss of vision in the eye

pelvic pain

persistent crusting or scaling of nipple

pinpoint red or purple spots on the skin

prominent superficial veins over affected area

red, irritated eyes

redness or swelling of the breast

sensitivity to the sun

severe headaches of sudden onset

skin thinness

skin warmth

slow speech

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stomach discomfort, upset, or pain

sudden loss of consciousness

sudden loss of coordination

sudden onset of shortness of breath for no apparent reason

sudden onset of slurred speech

sudden vision changes

swelling of the abdominal or stomach area

swelling of the fingers or hands



unpleasant breath odor

unusual tiredness or weakness


vomiting of blood

weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abnormal growth filled with fluid or semisolid material

accidental injury

bladder pain

bloated full feeling

bloody or cloudy urine

body aches or pain

coating or white patches on tongue


cough producing mucus

decrease in amount of urine

difficult, burning, or painful urination


dryness of the throat

ear congestion or pain

excess air or gas in the stomach or intestines


feeling of warmth

feeling sad or empty

frequent urge to urinate

general feeling of discomfort or illness

headache, severe and throbbing

increased clear or white vaginal discharge


itching of the vaginal, rectal or genital areas

lack of appetite

lack or loss of strength

loss of interest or pleasure

mild dizziness

neck pain



pain during sexual intercourse

painful or difficult urination

pain or tenderness around the eyes and cheekbones

passing gas

redness of the face, neck, arms, and occasionally, upper chest

runny nose

skin irritation or redness where skin patch was worn




sore mouth or tongue

stuffy nose

sudden sweating

tender, swollen glands in the neck

thick, white vaginal discharge with no odor or with a mild odor


trouble concentrating

trouble sleeping

unable to sleep

voice changes

Less common

Blemishes on the skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning or stinging of the skin

diarrhea (mild)

difficulty with moving

dizziness (mild)

increased hair growth, especially on the face

lower abdominal or stomach pain or pressure

mood or mental changes

muscle stiffness

painful cold sores or blisters on the lips, nose, eyes, or genitals


pounding in the ears

problems in wearing contact lenses

slow heartbeat

tooth or gum pain

unusual decrease in sexual desire (in males)

unusual increase in sexual desire (in females)

white or brownish vaginal discharge

Incidence not known

Abnormal turning out of cervix

changes in appetite

dull ache or feeling of pressure or heaviness in the legs

flushed, dry skin

fruit-like breath odor

increased hunger


large amount of triglyceride in the blood

leg cramps

patchy brown or dark brown discoloration of the skin

poor insight and judgment

problems with memory or speech

trouble recognizing objects

trouble thinking and planning

trouble walking

twitching, uncontrolled movements of the tongue, lips, face, arms, or legs

unexpected or excess milk flow from the breasts

Also, many women who are taking estrogens with a progestin (another female hormone) will start having monthly vaginal bleeding, similar to menstrual periods, again. This effect will continue for as long as the medicine is taken. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy).

This medicine may cause loss or thinning of the scalp hair in some people.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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